How Does Ivermectin Reduce Cancerous Tumors?

ByPrimary Researcher

Executive Summary

  • Ivermectin has multiple impressive ways it fights against cancer in prevention and treatment, and one of these is how it reduces tumors.

Introduction

In a previous article titled How Ivermectin Is Useful for Treating Cancer, we covered the evidence for the benefits of Ivermectin for cancer. But to understand the impact of Ivermectin on cancer, it is essential to know how many different ways Ivermectin has this impact.

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Mechanism #6: Anti-Tumor Effects

This quotation explains how Ivermectin fights Tumors.

The Many Cancers for Which Ivermectin Has Proven Effective in Fighting Tumors

Ivermectin has demonstrated its antitumor effects in different types of cancers, including ovarian cancer (OC), pancreatic cancer, colon cancer, breast cancer, glioblastoma, melanoma, prostate cancer, lung cancer, and leukemia.

This likely means that Ivermectin is effective against many cancers as the exact mechanisms work.

Furthermore, shrinking cancerous tumors is just one of the multiple ways that Ivermectin has proven effective against cancers, as covered in the article By How Many Different Mechanisms Does Ivermectin Fight Cancer?

Anti Tumor Activity

There is a continuously accumulating body of evidence that ivermectin may have substantial value in the treatment of a variety of cancers. The avermectins are known to possess pronounced antitumor activity, as well as the ability to potentiate the antitumor action of vincristine.

Over the past few years, there have been steadily increasing reports that ivermectin may have varying uses as an anti-cancer agent, as it has been shown to exhibit both anti-cancer and anti-cancer stem cell properties. An in silico chemical genomics approach designed to predict whether any existing drugs might be useful in tackling glioblastoma, lung and breast cancer, indicated that ivermectin may be a useful compound in this respect.

In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1-dependent growth. PAK proteins are essential for cytoskeletal reorganization and nuclear signaling, PAK1 being implicated in tumor genesis while inhibiting PAK1 signals induces tumor cell apoptosis (cell death).

PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors.

The following quote will address PAK1 yet again.

The Technical Details of How Ivermectin Works Against Tumors

The following quote from the article Anti-Parasite Drug Ivermectin Can Suppress Ovarian Cancer by Regulating lncRNA-EIF4A3-mRNA Axes explains how Ivermectin targets the chloride channel and more.

Important Point #1: Blocking Tumor Progression

The antitumor targets of ivermectin include chloride channel, PAK1 protein, NS3 DDX23 helicase, Akt/mTOR pathway, SIN3 domain, multi-drug resistance (MDR) protein, WNTTCF pathway, Nanog/Sox2/Oct4 genes, and P2X7/P2X7 receptors.