How Does Ivermectin Treat Neuropathy and Nerve Damage?

ByPrimary Researcher

Executive Summary

  • One of the surprising uses of Ivermectin is for neuropathy and nerve damage.
  • This article covers a study on how it works.

Article Summary

This article covers neuropathy and its frequency and how Ivermectin promotes nerve regeneration.

Introduction

The ability of Ivermectin to promote nerve regeneration is one of the most surprising applications of Ivermectin.

What is the Interest Level in the Search Topic Ivermectin Neuropathy?

The search for Ivermectin Neuropathy is a commonly searched ailment for Ivermectin. After reviewing the available articles on the Internet, we found very little coverage of the effectiveness of Ivermectin for neuropathy, even though substantial research has been published in this area. In response, we created articles covering the effectiveness of Ivermectin, including Ivermectin neuropathy.

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The Evidence on Ivermectin for Neuropathy

These quotes are from the article Ivermectin Promotes Peripheral Nerve Regeneration during Wound Healing.

Important Point #1: What is Neuropathy, and How Common Is It?

Approximately 20 million Americans sustain peripheral nerve damage resulting from medical disorders and/or trauma. For example, neuropathy, a condition that occurs upon peripheral nerve damage or disruption, often produces pain and/or loss of sensation and movement, and can result from diabetes, certain autoimmune diseases, human immunodeficiency virus infection, and chemotherapy treatment.

Chemotherapy is one of the most common causes of neuropathy.

Important Point #2: How Common Is Surgery for Neuropathy?

3–10% of all traumatic injuries result in acute peripheral nerve damage requiring surgical intervention. Fewer than half of traumatic injury patients who undergo surgical nerve repair regain good to excellent motor function and sensation.

This type of irreparable peripheral nerve damage can negatively affect a patient’s quality of life and may cause severe and permanent sensory and motor function defects that can result in complete paralysis or development of chronic neuropathic pain.

Important Point #3: How Does Ivermectin Work to Promote Nerve Regeneration

Although our in vitro results clearly demonstrated a role of ivermectin in promoting nerve regeneration through the transformation of dermal fibroblasts into a more glial-like phenotype, it was important to understand if these effects could also be seen in an in vivo model.

In this work, we provide a role for ivermectin in promoting peripheral nerve growth in mammals. We discovered that co-culturing hiNSCs with ivermectin-treated fibroblasts resulted in increased hiNSC proliferation and migration.

What We Can Learn Regarding Nerve Regeneration from the Axolotl

Scientists have been studying the Axolotl to understand its ability to regenerate parts of its body. This is explained in the following quote from the same paper. 

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