How Effective and What is the Cost and Cost Benefit of Ixifi?

ByPrimary Researcher

Executive Summary

  • Ixifi is taken for autoimmune disorders.
  • What was never done with Ixifi’s FDA approval was to evaluate any cost-benefit for this drug.

Introduction

Ixifi has significant side effects for improvement against autoimmune diseases. It also comes high costs and exaggerated benefits. This article will begin by discussing its financial costs and then move into covering its cost-benefit relationship.

The Ixifi Cost

Ixifi is an expensive drug and is administered by healthcare professionals. Generally, in the US Ixifi is around $30,000 per year.

How Effective is Ixifi Versus Autoimmune Diseases?

Studies of the effectiveness of Humira — which is very similar to Ixifi in clinical trials are covered in the article by Medical News Today.

Autoimmune Disease #1: Effectiveness For Ulcerative Colitis

Effectiveness for ulcerative colitis
Ixifi was studied in adults with moderate to severe UC that was active. These people had either tried or were currently taking other drugs for UC called immunosuppressants.

In clinical studies, researchers wanted to see if Ixifi was better than a placebo at causing symptoms to go into remission. In one study, 18.5% of people who took Ixifi had symptom remission after 8 weeks, compared with 9.2% of people who took a placebo.

This is an improvement of (18.5-9.2) or 9.3 percentage points.

A similar study found that 16.5% of people who took Ixifi had symptom remission after 8 weeks, compared with 9.3% of people who took a placebo. At 52 weeks, 8.5% of people who took Ixifi were still in symptom remission, compared with 4.1% of people who took a placebo.

This is a 7.2 percentage point and 4.4% percentage point improvement, respectively.

Study results in children

Ixifi was studied in children ages 5 years and older with moderate to severe UC that was active. The children had already tried or were currently taking certain other drugs for UC. These drugs included corticosteroids, an immunomodulator, or a TNF blocker.

In clinical studies, researchers looked at whether certain dosages of Ixifi were better than a placebo at causing remission of UC symptoms. After 8 weeks of treatment, 60% of children who took the recommended dosage of Ixifi experienced remission. Also, 43% of children who took a lower Ixifi dosage experienced remission of their symptoms.

This is a 17 percentage point improvement.

After a total of 52 weeks of treatment, 45% of children who took the recommended Ixifi dosage experienced remission of their UC symptoms. This is compared to 29% of children who took a lower Ixifi dosage, and 33% of children who took a placebo.

This is a 12% percentage point improvement versus the placebo.

Autoimmune Disease #2: Effectiveness For Crohn’s Disease

In clinical studies, people with CD were treated with either Ixifi (at various doses) or a placebo. Researchers found that 21% to 36% of people who took Ixifi had a CD remission by week 4. This is compared with 7% to 12% of people who took a placebo.

This is an improvement of between 14 percentage points and 24 percentage points.