Executive Summary

• We received a question on the use of Ivermectin for Crohn’s disease.

Introduction

Ivermectin is a very important immunomodulator. However, it is very rare to hear about Ivermectin for autoimmune disorders. However, we received a question on just this topic.

Ivermectin for Crohn’s Disease?

I am reaching out because I have been taking Humira for the past 6 yrs for treating my Crohn’s disease. I have been researching alternatives more holistic approach but am a little nervous just trying things without a little guidance from people who know more. I am a patient at the Mayo Clinic but have lost my faith and respect in them. I have changed a lot of my diet and eat mostly organic and only purchase meat from a local farmer with no antibiotic and grass fed only beef. I understand you may not be able to provide medical advice but was just wondering if you know if anyone has had success in treating other illnesses besides cancer like Crohn’s disease with ivermectin? Any insight would be appreciated.

Our Answer

Yes, we have. Cancer and autoimmune disease have the same core issue- immune system dysfunction. In the case of autoimmune disorders, the immune system overreacts; in the case of cancer, the immune system underreacts. Overall, the public and medical establishment think of autoimmune disease in these terms (of a poorly performing immune system), but not cancer. As an example of how tightly we consider the relationship, we have been developing a specification for a supplement that would be useful for cancer and autoimmune patients — or anyone who wants a more robust immune system.

Why do we frame the topic in those terms?

Because it is all highly related, we have been testing the specification on ourselves even though none of us have either cancer or autoimmune disease because after reading the material (not all of us do research; some of us do other things), we all want the best possible immune system we can have.

According to Drugs.com — a highly biased extension of the medical establishment, Humira is one of the tops reviewed drugs — however, according to this commenter, this drug — taken for six years has not been effective for her. 

Humira is used for many autoimmune diseases. However, Humira has never been tested against Ivermectin. I know this because I checked and could not find any comparison. How this could be the case is quite impressive. There are many studies and interest in Ivermectin for treating covid. However, one of the ways that Ivermectin works for covid is to reduce inflammation, which is again due to Ivermectin’s immunomodulatory effect. This same effect will have an impact on autoimmune diseases. 

Impacts of Ivermectin on Cancer

The following are how Ivermectin works against cancer.

Impact #1: Inhibiting Proliferation of Tumor Cells

Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways.

The Ivermectin blocking of PAK1 proteins, aka activated kinase, is a reason for this.

The instrumentality of PAK1 in cancer growth is explained in the following quotation from the article Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations.

Impact #2: Inhibiting Metastasis

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells.

Metastasis is how cancer spreads, and I cover this in detail in the article How Does Metastasis Work in the Body?

Impact #3: Promoting Apoptosis & Pyropoptsis

ivermectin promotes programmed cancer cell death, including apoptosis, autophagy, and pyropoptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Second, IVM seems to induce mixed cell death in tumor cells, which is also a controversial issue

A significant issue with the dysfunction of cancer is that the cancerous cells refuse instructions from the immune system to commit suicide -- or what is scientifically referred to as apoptosis. I cover apoptosis in the article How Ivermectin Improves Cancer Prevention and Treatment Through Improving Apoptosis or Programmed Cell Death.

Pyropoptosis is a type of apoptosis that is caused by inflammation.

Impact #4: Promoting Autophagy

Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells.

Autophagy clears away cells and recycles them. Different things can trigger more autophagy. I cover autophagy in the article Is Autophagy Effective Against Cancer?

Impact #5: Inhibit Cancer Cell Proliferation Through Inhibiting YAP1 Activity

Lung cancer has the highest morbidity and mortality among cancers. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity.

Conclusion

There is ample evidence that Ivermectin is helpful against many different types of cancers. It is unlikely that these are the only cancers for which Ivermectin is effective, but the studies we have found so far show that Ivermectin works to combat and prevent it. Ivermectin is an immuno-modulator, so it has beneficial effects not only for cancer -- as one of the mechanisms of how Ivermectin works is improving the immune system, which means it improves the immune system against cancer and other diseases.

Regarding the dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.

Why Are Anti-Parasitic Drugs Effective Against Cancer?

To understand why this class of drugs works against cancer, see the article The Mechanism of How Anti-Parasitic Drugs Work to Mitigate Cancer.

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing. 

• We have Ivermectin dosage calculators based on research studies and for all the different uses of Ivermectin.
• We are the only web source offering an Ivermectin dosage calculator in addition to different dosage estimates for different cancer types.
• All of our calculators are easy to use (see our dosage calculator listing). Each person enters their personalized information into the calculator and receives our recommended extensively researched dosage estimate automatically and immediately calculated.
• We also cover the broader problems with dosage calculation in medicine at the article The Problem With Dosage Calculation in Medicine, as this is an issue much larger than for one drug. 

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing. 

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