The Role of Ivermectin in Reducing Inflammation From Covid

Executive Summary

• Multiple studies show Ivermectin reduces inflammation in those with covid.
• This study is of no interest to the medical establishment or establishment media.

Introduction

Understanding the role chronic inflammation plays in cancer and how Ivermectin fights this issue is critical to understanding one of the powerful effects of Ivermectin.

What is Inflammation?

Inflammation is part of the immune response. So, to be chronically inflamed is when the immune system is over-responding and, therefore, can be categorized the same way as an auto-immune disease. Inflammation is part of immunity, and the immune response is explained in the following quotation from Sound Sleep Medical.

Inflammation is your body’s way of defending itself against bacteria, viruses, or damaged cells, and it occurs naturally as part of the natural healing process. The inflammation, which can cause you a lot of pain and discomfort, is removing the harmful pathogens from your body. A rapid inflammation, in response to a broken bone, or a viral infection, can cause swelling for a few days and dissipate quickly. This inflammation is helping your body heal itself, and it’s not a bad thing. However, if you suffer from a chronic and ongoing inflammation, it’s a sign that your body isn’t healing itself, and you’ll struggle with chronic pain and stress.

Getting poor sleep increases inflammation. Stress increases inflammation.

Why is this?

These two things are not viruses or other pathogens.

The answer is that the immune system perceives poor sleep and stress as a type of attack on the body, and the immune system is alert through these two examples. Those with poor sleep and stress are at very high risk for chronic inflammation. Furthermore, these things are all interactive. So, a person with chronic inflammation will have a problem sleeping. Moreover, it does not take chronic sleep deprivation to cause inflammation, and one night will cause inflammation to rise, as is explained in the following quotation from Science Daily.

A new article in the September 15th issue of Biological Psychiatry, by the UCLA Cousins Center research team, reports that losing sleep for even part of one night can trigger the key cellular pathway that produces tissue-damaging inflammation. The findings suggest a good night’s sleep can ease the risk of both heart disease and autoimmune disorders such as rheumatoid arthritis.

Understanding Inflammation and Covid

A significant effect of COVID-19 is inflammation, and Antiinflammatories are part of the US COVID-19 treatment protocol. The medical establishment ignored the article published in 2020 titled Ivermectin may be a clinically useful antiinflammatory agent for late-stage COVID-19, as it tells a story of effectiveness against covid — which they don’t want to be told.

Ivermectin, on the WHO’s List of Essential Medications, has been in clinical use since 1981 as an orally and topically active agent for treating a range of parasitic infections in humans, including river blindness and lymphatic filariasis. It is also widely used in veterinary practice.

Anecdotally, the use of the standard clinical dose of ivermectin, 9 mg once, has been associated with some cases of rapid clinical resolution in severe hospitalised COVID-19; clinical studies evaluating its utility in this regard are underway.

There are two reports that ivermectin, administered either systemically or topically, exerts anti-inflammatory effects in murine models of allergic inflammation (asthma and atopic dermatitis). The systemic effect was achieved with a 2 mg/kg dose.

In 2008, Zhang et al studied the impact of ivermectin in mice challenged with intraperitoneal lipopolysaccharide (LPS). They chose a dose of LPS that induced 100% mortality within 5 days. They then demonstrated that oral ivermectin, administering 2 hours prior to LPS, dose dependently reduced mortality in the LPS-treated mice, with a significant 50% reduction in mortality being achieved at a 4 mg/kg dose.3 In vitro studies likewise confirmed the ability of this agent to block cytokine production by LPS-challenged macrophages.

When we extrapolate this dose from 20 g mice to 70 kg humans, using the two-thirds power of relative body mass (ratio of body surface areas) as a correction factor, 4 mg/kg in mice corresponds to about 18 mg in humans—double the standard clinical dose. Allometric scaling by the three-fourths power (Kleiber’s law) yields a dose of 36 mg.

A study of related interest, published a year later, examined the impact of ivermectin—a group of 16-membered macrocyclic lactone derivatives of which ivermectin is a member—on LPS signalling in the RAW 264.7 murine macrophage-derived cell line. In concentrations ranging from 0.625 to 5 mg/L, ivermectin suppressed activation both of NF-kappaB and the stress-activated MAP kinases JNK and p38.

Moreover, there are two reports that ivermectin, administered either systemically or topically, exerts anti-inflammatory effects in murine models of allergic inflammation (asthma and atopic dermatitis). The systemic effect was achieved with a 2 mg/kg dose.

As the impact of ivermectin on antiviral immunity has not been studied, it is unclear whether it would be prudent to withhold its use until later-stage COVID-19.

Conclusion

The medical establishment has repeatedly stated that Ivermectin is useless against COVID-19, yet how it reduces inflammation is central to fighting COVID-19. This is only one of several ways that Ivermectin works against covid.

Addressing the Damage

One of the best ways to address the damage caused by the covid vaccines is with Ivermectin. This is the reason I began taking Ivermectin -- before investigating all the other health benefits of the drug. Now, I take Ivermectin for many reasons.

• We have Ivermectin dosage calculators based on research studies and for all the different uses of Ivermectin.
• We are the only web source offering an Ivermectin dosage calculator in addition to different dosage estimates for different cancer types.
• All of our calculators are easy to use (see our dosage calculator listing). Each person enters their personalized information into the calculator and receives our recommended extensively researched dosage estimate automatically and immediately calculated.
• We also cover the broader problems with dosage calculation in medicine at the article The Problem With Dosage Calculation in Medicine, as this is an issue much larger than for one drug. 

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing.