The Testing Evidence for Using Ivermectin for Treating Canine Melanoma

ByPrimary Researcher

Executive Summary

  • This article covers the evidence I could find for Ivermectin as a treatment for Canine Melanoma.

Introduction

In this article, I cover the effectiveness of Ivermectin versus Canine Melanoma.

In many articles on this site, such as the article How Ivermectin Is Useful for Treating Cancer we covered the evidence for the benefits of Ivermectin for cancer. However, the topic of which specific cancers Ivermectin has been proven effective is a constant source of questions.

There are a lot of quotes in this article, but I have a short one for each cancer type. The article uses the term “IVM” to mean Ivermectin.

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There are a lot of quotes in this article, but I have a short one for each cancer type. This study uses the term “IVM” to mean Ivermectin.

Cancer Type #6: Canine Melanoma

Melanoma is the most common malignant skin tumor with a high mortality rate. Drugs targeting BRAF mutations such as vemurafenib, dabrafenib and PD-1 monoclonal antibodies, including pembrolizumab and nivolumab have greatly improved the prognosis of melanoma. Gallardo treated melanoma cells with IVM and found that it could effectively inhibit melanoma activity. Interestingly, IVM could also show activity against BRAF wild-type melanoma cells, and its combination with dapafinib could significantly increase antitumor activity. Additionally, it has been confirmed that PAK1 is the key target of IVM that mediates its anti-melanoma activity, and IVM can also significantly reduce the lung metastasis of melanoma in animal experiments. Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells. However, NAC reversed the effect of IVM, which indicated that IVM increased TFE3-dependent autophagy through the ROS signaling pathway.

This metanalysis study was published on the NIH or National Institutes of Health website. However, it was funded by Indian science institutes.

Regarding the dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.

Two Example Areas Where Ivermectin is Proven to Fight Cancer

However, at a high level, two critical and common areas that IVM helps with are the following:

Beneficial Area #1: Ivermectin and Apoptosis

Apostosis is the technical term for programmed cell death. The cells in a body need to respond to chemical messengers, and it is time for cells to die.

Beneficial Area #2: Ivermectin’s Effect on Immunomodulation

Immunomodulation is the calibration of the immune system so that it responds appropriately.

How Ivermectin is Complementary With Conventional Cancer Treatments

IVM not only does not interfere with conventional cancer treatments but there are several treatments; chemotherapy is one example, for which Ivermectin is complementary. I cover this in the topic How Ivermectin Helps Reduce Chemotherapy Drug Resistance in Cancer Cells.