The Testing Evidence for Using Ivermectin for Treating CML

Executive Summary

• This article covers the evidence I could find for Ivermectin as a treatment for CML.

Article Summary

Studies demonstrate that Ivermectin is effective against cancer, we then cover how Ivermectin works against cancer by explaining the mechanisms of action, and then the impacts of Ivermectin on cancer.

Introduction

This article provides an overview covering the evidence for Ivermectin versus CML.

In many articles on this site, such as the article How Ivermectin Is Useful for Treating Cancer we covered the evidence for the benefits of Ivermectin for cancer. However, the topic of which specific cancers Ivermectin has been proven effective is a constant source of questions.

There are a lot of quotes in this article, but I have a short one for each cancer type. The article uses the term “IVM” to mean Ivermectin.

What is the Interest Level in the Search Topic Ivermectin CML?

The search for Ivermectin CML is a commonly searched cancer type concerning Ivermectin. After reviewing the available articles on the Internet, we found there is very little coverage of the effectiveness of Ivermectin for many specific types of cancer. In response, we created articles covering the effectiveness of Ivermectin for nearly all different cancers, including Ivermectin CML. You can see our full list of articles on the topic of Ivermectin versus the different cancers at The Cancers For Which Ivermectin Has Been Demonstrated to be Effective.

Cancer Type #5: CML

This quote is from the article Identification of Ivermectin Induces Apoptosis Through Mitochondrial Dysfunction in CML Cells.

Ivermectin, an antihelminthic, causes apoptosis of chronic myeloid leukemia (CML) cells and CML CD34 stem/progenitor cells through oxidative stress and mitochondrial dysfunction, according to a study published in Biochemical and Biophysical Research Communications.

Treatment with ivermectin resulted in caspase-dependent apoptosis of CD34 and K562 CML cells, but not normal CD34 cells. Apoptosis occurred in about 30% of CML CD34 or K562 CML cells when treated with a TKI or ivermectin monotherapy. The combination of ivermectin and a TKI, however, increased the frequency of apoptosis to about 95%, suggesting that the combination has a synergistic effect.

Ivermectin showed cytotoxicity (the ability to damage or kill) cancer cells.

Ivermectin decreased basal and maximal mitochondrial respiration in CML CD34, K562 CML cells, and normal cells, and decreased the mitochondrial respiratory complex I in CML and normal CD34 cells. Ivermectin also increased levels of ROS and superoxide, both markers of mitochondrial dysfunction.

This means that Ivermectin disrupted the mitochondrial metabolism. This is very important because the immune system identifies cells with dysregulated metabolism for disposal.

PAK1 is implicated in multiple cancers if found in the quotation from the article Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.

Previous studies showed that PAK-1 mediated the growth of prostate PC-3 cell tumor xenografts in athymic nude mice as well as the transforming growth factor-β (TGFβ)-induced prostate cancer cell epithelial-mesenchymal transition (EMT). These studies suggested that PAK-1 plays a major role in prostate cancer progression and is a potential target for prostate cancer therapy. PAK-1 has also been suggested to be involved in the early stages of breast cancer and may partially participate in the mechanisms mediating the transformation of mammary epithelial cells into mesenchymal malignant cells.

The Mechanisms by Which Ivermectin Works Against Cancer

Confidence in Ivermectin being effective for many cancer types also comes from understanding the specific mechanisms by which Ivermectin works against cancer. I cover this topic in detail in the article By How Many Different Mechanisms Does Ivermectin Fight Cancer?

More About The C19Early Clinical Trial Comparison Website

The C19early.com website tracks clinical trials. It is the best source of information on the studies of the effectiveness based upon clinical trials of different treatments for covid. However, it is more than this - as it is a model for how clinical trials should be communicated to the public so the extraordinarily corrupt medical establishment does not control the information. And it is the website that the medical establishment would like banned from the Internet.

One of the things the C19Early website showed was that early treatment significantly impacted the outcomes against covid.

The Benefit of Early Treatment

Notice that the earlier the treatment is used, the better the outcomes. Naturally, early treatment is measured in days with a respiratory disease like COVID-19, while in months with a disease like cancer. So the timings are different, but the principle is the same. 

Even though this website does not track cancer clinical trials (unfortunately, no website does), the site holds essential observations. For one, a person's response to covid is like their response to cancer, greatly dependent upon the strength and health of their immune system.

Things like Zinc, Ivermectin, and Fenbendazole all empower the immune system and are, therefore, effective in the treatment and prevention of both COVID and cancer. 

Offering Cancer Prevention as Well as Treatment

What is better than treatment is prevention. For anyone who is concerned with cancer prevention, both a very healthy lifestyle and diet, as well as things like Ivermectin and or Fenbendazole, are things that can be taken both as a treatment and as a preventative. We cover all these topics and the supporting specifics on our subscription website. 

Impacts of Ivermectin on Cancer

The following are how Ivermectin works against cancer.

Impact #1: Inhibiting Proliferation of Tumor Cells

Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways.

The Ivermectin blocking of PAK1 proteins, aka activated kinase, is a reason for this.

The instrumentality of PAK1 in cancer growth is explained in the following quotation from the article Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations.

Impact #2: Inhibiting Metastasis

Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells.

Metastasis is how cancer spreads, and I cover this in detail in the article How Does Metastasis Work in the Body?

Impact #3: Promoting Apoptosis & Pyropoptsis

ivermectin promotes programmed cancer cell death, including apoptosis, autophagy, and pyropoptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Second, IVM seems to induce mixed cell death in tumor cells, which is also a controversial issue

A significant issue with the dysfunction of cancer is that the cancerous cells refuse instructions from the immune system to commit suicide -- or what is scientifically referred to as apoptosis. I cover apoptosis in the article How Ivermectin Improves Cancer Prevention and Treatment Through Improving Apoptosis or Programmed Cell Death.

Pyropoptosis is a type of apoptosis that is caused by inflammation.

Impact #4: Promoting Autophagy

Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells.

Autophagy clears away cells and recycles them. Different things can trigger more autophagy. I cover autophagy in the article Is Autophagy Effective Against Cancer?

Impact #5: Inhibit Cancer Cell Proliferation Through Inhibiting YAP1 Activity

Lung cancer has the highest morbidity and mortality among cancers. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity.

Conclusion

There is ample evidence that Ivermectin is helpful against many different types of cancers. It is unlikely that these are the only cancers for which Ivermectin is effective, but the studies we have found so far show that Ivermectin works to combat and prevent it. Ivermectin is an immuno-modulator, so it has beneficial effects not only for cancer -- as one of the mechanisms of how Ivermectin works is improving the immune system, which means it improves the immune system against cancer and other diseases.

Regarding the dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.

Why Are Anti-Parasitic Drugs Effective Against Cancer?

To understand why this class of drugs works against cancer, see the article The Mechanism of How Anti-Parasitic Drugs Work to Mitigate Cancer.

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing.