The Testing Evidence for Using Ivermectin for Treating Metastatic Adenocarcinoma
Executive Summary
- This article covers the evidence I could find for Ivermectin as a treatment for Metastatic Adenocarcinoma.
Article Summary
Studies demonstrate that Ivermectin is effective against cancer, we then cover how Ivermectin works against cancer by explaining the mechanisms of action, and then the impacts of Ivermectin on cancer.
Introduction
This article provides an overview covering the evidence for Ivermectin versus Metastatic Adenocarcinoma.
In many articles on this site, such as the article How Ivermectin Is Useful for Treating Cancer we covered the evidence for the benefits of Ivermectin for cancer. However, the topic of which specific cancers Ivermectin has been proven effective is a constant source of questions.
There are a lot of quotes in this article, but I have a short one for each cancer type. The article uses the term “IVM” to mean Ivermectin.
What is the Interest Level in the Search Topic Ivermectin Metastatic Adenocarcinoma?
The search for Ivermectin Metastatic Adenocarcinoma is a commonly searched cancer type concerning Ivermectin. After reviewing the available articles on the Internet, we found there is very little coverage of the effectiveness of Ivermectin for many specific types of cancer. In response, we created articles covering the effectiveness of Ivermectin for nearly all different cancers, including Ivermectin Metastatic Adenocarcinoma. You can see our full list of articles on the topic of Ivermectin versus the different cancers at The Cancers For Which Ivermectin Has Been Demonstrated to be Effective.
About the Brightwork Research Treatment Database
We have a subscription website that provides people with everything they need to know about using Ivermectin for several diseases. Cancer is just one of our most researched areas. To see more see the below article indexes.
Article Indexes
- Open this link to see just one example Ivermectin article index.
- Open this link to see the full article index.
We have the most research on Ivermectin and Ivermectin for cancer and are completely independent. However, we have to charge subscribers to stay independent. We have free articles that expose readers to our research and writing -- however most of our content is behind a paywall.
Cancer Type #16: Metastases
The following quote is from the article Ivermectin inhibits tumor metastasis by regulating the Wnt/β-catenin/integrin β1/FAK signaling pathway.
Tumor metastasis is the major cause of cancer mortality; therefore, it is imperative to discover effective therapeutic drugs for anti-metastasis therapy. In the current study, we investigated whether ivermectin (IVM), an FDA-approved antiparasitic drug, could prevent cancer metastasis.
Colorectal and breast cancer cell lines and a cancer cell-derived xenograft tumor metastasis model were used to investigate the anti-metastasis effect of IVM.
Our results showed that IVM significantly inhibited the motility of cancer cells in vitro and tumor metastasis in vivo.
Mechanistically, IVM suppressed the expressions of the migration-related proteins via inhibiting the activation of Wnt/β-catenin/integrin β1/FAK and the downstream signaling cascades.
Our findings indicated that IVM was capable of suppressing tumor metastasis, which provided the rationale on exploring the potential clinical application of IVM in the prevention and treatment of cancer metastasis.
This highlights two different ways that Ivermectin suppressed metastasis.
The following quote is more technical and provides more detail — however, the conclusion is that Ivermectin works against metastasis.
Many studies have demonstrated that IVM caused cell death in cancer cell lines through modulating signaling pathways, including Hippo and Akt/mTOR pathways [37,38].
We found that IVM also inhibited the migration of the EGFR-KO cells (Figure 12A-D), similar to that observed in wildtype HCT-116 cells (Figure 1D). IVM inhibited the activation of Wnt/β-catenin/integrin β1/FAK signaling pathways and the expression of the downstream signaling molecules in both EGFR-KO cells and the wildtype cells (Figure 12E), suggesting that the EGFR was not required for IVM inhibition of cell motility. Wnt/β-catenin and integrin β1/FAK signaling pathways have been known to play critical roles in regulating tumor metastasis [19,20].
Testing Evidence for Ivermectin
The following quotes are from the article Ivermectin, a potential anticancer drug derived from an antiparasitic drug.
Impact #1: Inhibiting Proliferation of Tumor Cells
Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways.
The Ivermectin blocking of PAK1 proteins, aka activated kinase, is a reason for this.
The instrumentality of PAK1 in cancer growth is explained in the following quotation from the article Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations.
In human ovarian cancer and NF2 tumor cell lines, high-dose ivermectin inactivates protein kinase PAK1 and blocks PAK1-dependent growth.
PAK proteins are essential for cytoskeletal reorganization and nuclear signaling, PAK1 being implicated in tumor genesis while inhibiting PAK1 signals induces tumor cell apoptosis (cell death).
PAK1 is essential for the growth of more than 70% of all human cancers, including breast, prostate, pancreatic, colon, gastric, lung, cervical and thyroid cancers, as well as hepatoma, glioma, melanoma, multiple myeloma and for neurofibromatosis tumors.
PAK1 becomes hyperactive in cancer cells for reasons that are not yet understood.
Ivermectin can be viewed as a PAK1 restrictor or modulator (I say modulator as PAK1 is present in normal healthy cells, but an overage of PAK is a prime cause of cancer.)
This means that Ivermectin interferes with a precursor to cancer. This modulating influence on PAK is another reason Ivermectin is effective against many types of cancer.
PAK1 is implicated in multiple cancers if found in the quotation from the article Effect of P21-activated kinase 1 (PAK-1) inhibition on cancer cell growth, migration, and invasion.
Previous studies showed that PAK-1 mediated the growth of prostate PC-3 cell tumor xenografts in athymic nude mice as well as the transforming growth factor-β (TGFβ)-induced prostate cancer cell epithelial-mesenchymal transition (EMT). These studies suggested that PAK-1 plays a major role in prostate cancer progression and is a potential target for prostate cancer therapy. PAK-1 has also been suggested to be involved in the early stages of breast cancer and may partially participate in the mechanisms mediating the transformation of mammary epithelial cells into mesenchymal malignant cells.
Hyperactive PAK1 and Cancer
This is explained in the quotation from P21 Activated Kinase-1 (Pak1) Promotes Prostate Tumor Growth and Microinvasion via Inhibition of Transforming Growth Factor β Expression and Enhanced Matrix Metalloproteinase 9 Secretion.
Even though Pak1 has been identified in normal prostatic epithelial cells and cancer cells, its specific role in the development of prostate cancer remains unclear. We report here that highly invasive prostate cancer cells express significantly higher levels of Pak1 protein compared with non-invasive prostate cancer cells. Furthermore, prostate tumor tissues and prostate cancer metastasized to lungs showed a higher expression of Pak1 compared with normal tissues.
This appears to match the experience with other cancers, but they have not performed sufficient studies to say for sure.
The Mechanisms by Which Ivermectin Works Against Cancer
Confidence in Ivermectin being effective for many cancer types also comes from understanding the specific mechanisms by which Ivermectin works against cancer. I cover this topic in detail in the article By How Many Different Mechanisms Does Ivermectin Fight Cancer?
More About The C19Early Clinical Trial Comparison Website
The C19early.com website tracks clinical trials. It is the best source of information on the studies of the effectiveness based upon clinical trials of different treatments for covid. However, it is more than this - as it is a model for how clinical trials should be communicated to the public so the extraordinarily corrupt medical establishment does not control the information. And it is the website that the medical establishment would like banned from the Internet.
One of the things the C19Early website showed was that early treatment significantly impacted the outcomes against covid.
The Benefit of Early Treatment
Notice that the earlier the treatment is used, the better the outcomes. Naturally, early treatment is measured in days with a respiratory disease like COVID-19, while in months with a disease like cancer. So the timings are different, but the principle is the same.
Even though this website does not track cancer clinical trials (unfortunately, no website does), the site holds essential observations. For one, a person's response to covid is like their response to cancer, greatly dependent upon the strength and health of their immune system.
Things like Zinc, Ivermectin, and Fenbendazole all empower the immune system and are, therefore, effective in the treatment and prevention of both COVID and cancer.
Offering Cancer Prevention as Well as Treatment
What is better than treatment is prevention. For anyone who is concerned with cancer prevention, both a very healthy lifestyle and diet, as well as things like Ivermectin and or Fenbendazole, are things that can be taken both as a treatment and as a preventative. We cover all these topics and the supporting specifics on our subscription website.
Impacts of Ivermectin on Cancer
The following are how Ivermectin works against cancer.
Impact #1: Inhibiting Proliferation of Tumor Cells
Recently, ivermectin has been reported to inhibit the proliferation of several tumor cells by regulating multiple signaling pathways.
The Ivermectin blocking of PAK1 proteins, aka activated kinase, is a reason for this.
The instrumentality of PAK1 in cancer growth is explained in the following quotation from the article Ivermectin: enigmatic multifaceted ‘wonder’ drug continues to surprise and exceed expectations.
Impact #2: Inhibiting Metastasis
Ivermectin has powerful antitumor effects, including the inhibition of proliferation, metastasis, and angiogenic activity, in a variety of cancer cells.
Metastasis is how cancer spreads, and I cover this in detail in the article How Does Metastasis Work in the Body?
Impact #3: Promoting Apoptosis & Pyropoptsis
ivermectin promotes programmed cancer cell death, including apoptosis, autophagy, and pyropoptosis. Ivermectin induces apoptosis and autophagy is mutually regulated. Second, IVM seems to induce mixed cell death in tumor cells, which is also a controversial issue
A significant issue with the dysfunction of cancer is that the cancerous cells refuse instructions from the immune system to commit suicide -- or what is scientifically referred to as apoptosis. I cover apoptosis in the article How Ivermectin Improves Cancer Prevention and Treatment Through Improving Apoptosis or Programmed Cell Death.
Pyropoptosis is a type of apoptosis that is caused by inflammation.
Impact #4: Promoting Autophagy
Deng found that IVM could activate the nuclear translocation of TFE3 and induce autophagy-dependent cell death by dephosphorylation of TFE3 (Ser321) in SK-MEL-28 melanoma cells.
Autophagy clears away cells and recycles them. Different things can trigger more autophagy. I cover autophagy in the article Is Autophagy Effective Against Cancer?
Impact #5: Inhibit Cancer Cell Proliferation Through Inhibiting YAP1 Activity
Lung cancer has the highest morbidity and mortality among cancers. Nishio found that IVM could significantly inhibit the proliferation of H1299 lung cancer cells by inhibiting YAP1 activity.
Conclusion
There is ample evidence that Ivermectin is helpful against many different types of cancers. It is unlikely that these are the only cancers for which Ivermectin is effective, but the studies we have found so far show that Ivermectin works to combat and prevent it. Ivermectin is an immuno-modulator, so it has beneficial effects not only for cancer -- as one of the mechanisms of how Ivermectin works is improving the immune system, which means it improves the immune system against cancer and other diseases.
Regarding the dosage and sourcing of Ivermectin, see the article On the Topic of Ivermectin Dosage and Sourcing.
Why Are Anti-Parasitic Drugs Effective Against Cancer?
To understand why this class of drugs works against cancer, see the article The Mechanism of How Anti-Parasitic Drugs Work to Mitigate Cancer.
About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply
- We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
- You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
- We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing.