What is the Correct Ivermectin Dosage to Treat Cancer in Dogs and Cats?

Executive Summary

• Ivermectin is not only effective against cancer in humans, but it is also effective against cancer in many pets.
• We cover the dosage question for Ivermectin dogs and Ivermectin cats in this article.

Article Summary

This article covers the studies into the use of Ivermectin against cancer in Ivermectin cats and Ivermectin dogs, the problem with the general shortage of information and studies of Ivermectin for cancer in cats and dogs, what so many dosage estimations for cats and dogs are based upon, and the logic for using the human studies for the estimated dosage in cats and dogs.

Introduction

Ivermectin has been used for decades, both in humans and in animals. While it is not supported by the medical establishment for use against cancer in humans or animals, many studies state that it should be. This article will discuss the recommended Ivermectin dosage for animals to fight cancer.

What is the Interest Level in the Search Topic Ivermectin Cats and Ivermectin Dogs?

The search for Ivermectin Cats and Ivermectin Dogs are currently the most commonly searched terms concerning Ivermectin and animals. After reviewing the available articles on the Internet, we found there is very little coverage of the effectiveness of Ivermectin for many specific types of cancer. In response to this, we created articles that cover the effectiveness of Ivermectin for Ivermectin Cats and Ivermectin Dogs.

About the Brightwork Research Treatment Database

We have a subscription website that provides people with everything they need to know about using Ivermectin for several diseases. Cancer is just one of our most researched areas. To see more see the below article indexes. 

Article Indexes

• Open this link to see just one example Ivermectin article index.
• Open this link to see the full article index. 

We have the most research on Ivermectin and Ivermectin for cancer and are completely independent. However, we have to charge subscribers to stay independent. We have free articles that expose readers to our research and writing -- however most of our content is behind a paywall. 

Studies into the Use of Ivermectin Cats and Ivermectin Dogs

Here is one example of Ivermectin being tested on dogs. There are not very many studies of Ivermectin on dogs, so it made sense to include a few quotes from this study.

The following quotes are from the article Ivermectin Inhibits Canine Mammary Tumor Growth by Regulating Cell Cycle Progression and WNT Signaling.

Important Point #1: Inhibit Proliferation of Cancer Cells

Two canine mammary tumor cell lines were selected to demonstrate the efficacy of ivermectin in vitro. Ivermect ininhibited the proliferation of cancer cells with less effects on a normal canine epithelial cell line of the canine mammary tumor cell lines.

Additionally, ivermectin dramatically inhibited colony formation in a time-dependent manner. In order to further determine the inhibitory effect of ivermectin on tumor growth in vivo, tumor inhibition experiments were performed in canine mammary tumor xenografts. Consistent with the in vitro results, ivermectin-treated xenografts showed significant growth suppression without significant changes in mouse body weight or hepatic/renal toxicity(Fig. 6).

Important Point #2: What Was The Dosage Used?

The doses of ivermectin used in mouse xenograft studies are variable, from 5 to 40 mg/kg. In the present study, the dose of ivermectin was similar to thatin Huang et al. [8], which utilized 0.12 mg ivermectin/mouse/day in a breast cancer model. This dose of ivermectin is higher than that commonly used in dogs, but appeared well tolerated in the mice based on lack of body weight loss, elevations in serum hepatic/renal function markers and absence of pathologic changes. Thus, higher doses than the antiparasitic dose used commonly in dogs may be tolerable.

Caution should be made when select ivermectin as an anti-tumor drug for canine mammary tumor, since there is no references that show the dose necessary for the treatment of dogs is not toxic.

Futher studies are needed to be find the exact concentration of ivermectin which has the anti-tumor effects indogs without toxicity

This described a range of doses but did not provide examples of how one dosage level was better than another. This is the norm for studies not only on dogs but on humans as well.

The Shortage of Cancer Dosage Information for Ivermectin Cats and Ivermectin Dogs

The dosage generally listed on animal Ivermectin is for its use as an anti-parasitical. There are so few studies on using Ivermectin against cancer in animals, so it is impossible to propose a logical dosage based on these limited studies.

What Many of the Ivermectin Dosage Estimates Are Based Upon

The dosage information that is generally available on the Internet is often either deliberately too low or too infrequent (if provided by any website connected to the medical establishment that seeks to undermine the use of Ivermectin). Another common issue is that it is based upon the dosage for Ivermectin’s use when fighting parasites.

This is irrelevant for cats and dogs when looking for a dosage versus cancer.

Our dosage calculator is based on the studies of Ivermectin when used against cancers. However, again, we had to apply some judgment in the selection of the studies that ended up being included in the average that we used to develop our calculator.

Using The Human Studies of Ivermectin for Cancer to Approximate the Dosage for Animals

There are many more human studies for the use of Ivermectin versus cancer, which is what we based our dosage calculator on. I would not propose that this dosage has solid research to support it; instead, it assumes that animals use Ivermectin with a similar sensitivity to humans. Here is our Ivermectin dosage calculator for humans.

Therefore, even without having the studies for other animals (cats and dogs primarily), it makes sense to use Ivermectin at a dosage shown to work in humans rather than use any other basis I can point to, to develop the estimated dosage.

How the Low Toxicity of Ivermectin Plays Into the Dosage Estimation

Because Ivermectin has a low level of toxicity, there is virtually no chance that our calculated dosage level will be a problem for a cat or a dog. The drug is tolerated much higher than the recommended dosage. The only negative of taking a higher dose is that it costs more as more Ivermectin must be used. This is more of an issue for humans versus animals as animal Ivermectin is less expensive than human Ivermectin, and the average dog weight is considerably lower than that of the average human — and Ivermectin is dosed by body weight.

• We have Ivermectin dosage calculators based on research studies and for all the different uses of Ivermectin.
• We are the only web source offering an Ivermectin dosage calculator in addition to different dosage estimates for different cancer types.
• All of our calculators are easy to use (see our dosage calculator listing). Each person enters their personalized information into the calculator and receives our recommended extensively researched dosage estimate automatically and immediately calculated.
• We also cover the broader problems with dosage calculation in medicine at the article The Problem With Dosage Calculation in Medicine, as this is an issue much larger than for one drug. 

About Our Ivermecting Testing Program and Recommended Ivermectin Source of Supply

• We performed pharmaceutical testing on Ivermectin to find a lower-cost version that also matched Merck's original Ivermectin in bioequivalence.
• You can read about the details of our Ivermectin testing in this article, Our Ivermectin Bioequivalence Testing.
• We got Summit Products to carry this version of Ivermectin, which passed our bioequivalence testing. 

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